{"id":173,"date":"2021-09-24T12:02:53","date_gmt":"2021-09-24T10:02:53","guid":{"rendered":"http:\/\/mhh-kardiologie.de.w01d58f8.kasserver.com\/?page_id=173"},"modified":"2026-02-16T09:14:21","modified_gmt":"2026-02-16T08:14:21","slug":"molekulare-kardiologie-neue-mechanismen-und-therapiekonzepte","status":"publish","type":"page","link":"https:\/\/mhh-kardiologie.de\/en\/forschung\/molekulare-kardiologie-neue-mechanismen-und-therapiekonzepte\/","title":{"rendered":"Molekulare Kardiologie &#8211; Neue Mechanismen und Therapiekonzepte"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\" id=\"molekulare-kardiologie-neue-mechanismen-und-therapiekonzepte\">Molekulare Kardiologie &#8211; Neue Mechanismen und Therapiekonzepte<\/h2>\n\n\n\n<p>Kardiomyopathien, wie die peripartale Kardiomyopathie (PPCM), k\u00f6nnen zu einer Herzmuskelschw\u00e4che (Herzinsuffizienz) f\u00fchren. Der Schwerpunkt der Arbeitsgruppe \u201eMolekulare Kardiologie \u2013 Neue Mechanismen und Therapiekonzepte\u201c liegt dabei in der Aufkl\u00e4rung von Pathomechanismen und genetischen Ursachen, die zur Entstehung einer Herzinsuffizienz und speziell der PPCM, f\u00fchren k\u00f6nnen. Mit Hilfe dieser Erkenntnisse entwickeln wir in translationalen Ans\u00e4tzen Biomarker zur Diagnostik und neue Therapiekonzepte.<\/p>\n\n\n<div class=\"lazyblock-akkordeon-1hFKUf wp-block-lazyblock-akkordeon\">\n<input id=\"publikationen\" class=\"hide-akkordeon akkordeon-toggle\" type=\"checkbox\" tabindex=\"-1\">\n\n<div class=\"akkordeon-block\">\n  <div class=\"toggler\">\n    <label for=\"publikationen\" tabindex=\"0\">Publikationen<\/label>\n    <div class=\"akkordeon-bar\"><\/div>\n  <\/div>\n\n  <div class=\"akkordeon-content\">\n    <div class=\"akkordeon-inner-content\">\n      <div class=\"accordion\">\n<div class=\"inner\">\n<div class=\"ce_text block\">\n<ul>\n<li><strong>Heimerl M<\/strong>, <strong>Erschow S<\/strong>, <strong>M\u00fcller-Olling M<\/strong>, Manstein DJ, Decher N, Kauferstein S, Jenewein T, Pich A, <strong>Ricke-Hoch M<\/strong> and <strong>Hilfiker-Kleiner D<\/strong>. Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression. Eur Heart J. 2025 Feb 19:ehaf047.doi: 10.1093\/eurheartj\/ehaf047. Online ahead of print.<\/li>\n<li>Sliwa K, Jackson A, Viljoen C, Damasceno A, Mbanze I, Farhan HA, Yaseen IF, Mbakwem A, Dewi TI, Dzielinska Z, Abdullaev T, Goland S, <strong>Hilfiker-Kleiner D<\/strong>, Hahnle J, Basic C, Frogoudaki A, Seferovic P, van der Meer P, Petrie MC,<strong> Bauersachs J. <\/strong>Pregnancies in women after peri-partum cardiomyopathy: the global European Society of Cardiology EuroObservational Research Programme Peri-Partum Cardiomyopathy Registry. Eur Heart J. 2025 Feb 12:ehaf006. doi: 10.1093\/eurheartj\/ehaf006.<\/li>\n<li>Bahr FS, M\u00fcller FE, <strong>Kasten M<\/strong>, Benen N, Sieve I, Scherr M, Falk CS, <strong>Hilfiker-Kleiner D<\/strong>, <strong>Ricke-Hoch M<\/strong> and Ponimaskin E. Serotonin receptor 5-HT7 modulates inflammatory-associated functions of macrophages.<em> Cell Mol Life Sci.<\/em> (2025) 82(1):51. doi: 10.1007\/s00018-024-05570-z.<\/li>\n<li><strong>Schoenherr C<\/strong>, <strong>Pietzsch S<\/strong>, Barca C, M\u00fcller FE, Bahr FS, <strong>Kasten M<\/strong>, Zeug A, <strong>Erschow S<\/strong>, Falk CS, Ponimaskin E, Thackeray JT, <strong>Hilfiker-Kleiner D<\/strong> and <strong>Ricke-Hoch M<\/strong>. Immune-checkpoint-inhibitor therapy directed against PD-L1 is tolerated in the heart without manifestation of cardiac inflammation in a preclinical reversible melanoma mouse model. <em> Mol. Med.<\/em> 2025 4:1487526. doi: 10.3389\/fmmed.2024.1487526.<\/li>\n<li>Garcheva V, Sanchez Martinez C, Adel J, <strong>Pfeffer TJ<\/strong>, Akin M, <strong>Bauersachs J<\/strong>, Sch\u00e4fer A. Increased rate of anoxic brain damage with laryngeal tube compared to endotracheal intubation in patients with shockable out-of-hospital cardiac arrest \u2013 Experience from HAnnover COoling REgistry (HACORE). Resuscitation 2024 205:110416. doi:10.1016\/j.resuscitation.2024.110416.<\/li>\n<li>Sliwa K, Rakisheva A, Viljoen C, <strong>Pfeffer T<\/strong>, Simpson M, Jackson AM, Petrie MC, van der Meer P, Al Farhan H, Jovanova S, Mbakwem A, Sinagra G, Van Cra enenbroeck E, Hoevelmann J, Johnson MR, Mindham R, Chioncel O, Kahl KG, Rosano G, Tsch\u00f6pe C, Mebazaa A, Seferovic P, <strong>Bauersachs J<\/strong>. Eur J Heart Fail. 2024 26(10):2143-2154. doi: 10.1002\/ehjf.3377.<\/li>\n<li>van der Meer P, van Essen B, Viljoen C, B\u00f6hm M, Jackson A, <strong>Hilfiker-Kleiner D<\/strong>,\u00a0 Hoevelmann J, Mebazaa A, Farhan HA, Goland S, Ouwerkerk W, Petrie MC, Seferovic PM, Tromp J, Sliwa K, <strong>Bauersachs J<\/strong>. Bromocriptine treatment and outcomes in peripartum cardiomyopathy: the EORP PPCM registry. Eur Heart J. 2024 Sep 2:ehae559. doi: 10.1093\/eurheartj\/ehae559.<\/li>\n<li>Roh JD, Castro C, Yu A, Rana S, Shahul S, Gray KJ, Honigberg MC, <strong>Ricke-Hoch M<\/strong>, Iwamoto Y, Yeri A, Kitchen R, Guerra JB, Hobson R, Chaudhari V, Chang B, Sarma A, Lerchenm\u00fcller C, Al Sayed ZR, Verdugo CD, Xia P, Skarbianskis N, Zeisel A, <strong>Bauersachs J<\/strong>, Kirkland JL, Karumanchi SA, Gorcsan J, Sugahara M, Damp J, Hanley-Yanez K, Ellinor PT, Arany Z, McNamara DM, IPAC Investigators, Hilfiker-Kleiner D, Rosenzweig A. Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human. Sci Transl Med. 2024 Apr 17;16(743):eadi0077. doi:10.1126\/scitranslmed.adi0077.<\/li>\n<li>Bahr FS, <strong>Ricke-Hoch M<\/strong>, Ponimakin E, M\u00fcller FE. Serotonin Receptors in Myocardial Infarction: Friend or Foe? ACS Chem Neurosci. 2024 Apr 4. Doi: 10.1021\/acschemneuro.4c00031.<\/li>\n<li>Jackson AM, <strong>Bauersachs J<\/strong>, Petrie MC, van der Meer P, Laroche C, Farhan HA, Frogoudaki, Ibrahim B, Fouad DA, Damasceno A, Karaye K, Goland S, Maggioni AP, Briton O, Sliwa K; on behalf of the EURObservational Research Programme in conjunction with the Heart Failure Association of the European Society of Cardiology Committee on Peripartum Cardiomyopathies. Outcomes at 1 year in women with peripartum cardiomyopathy: Findings from the ESC EORP PPCM Registry. <em>EUR J Heart Fail.<\/em> 2023 Oct 12. doi: 10.1002\/ejhf.3055. Online ahead of print.<\/li>\n<li>Salloum FN, Tocchetti CG, Ameri P, Ardehali H, Asnani S, de Boer RA, Burridge P, Cabrera J-A, de Castro J, Cordoba R, Costa A, Dent S, Engelbertsen D, Fernandez-Velasco M, Fradley M, Fuster JJ, Galan-Arriola C, Garcia-Lunar I, Ghigo A, Gonzalez-Neira A, Hirsch E, Ibanez B, Kitsis RN, Konety S, Lyon AR, Martin P, Mauro AG, Mazo Vega MM, Meijers WC, Neilan TG, Rassaf T, <strong>Ricke-Hoch M<\/strong>, Sepulveda P, Thavendiranathan P, van der Meer P, Fuster V, Ky B, Lopez-Fernandez T, on behalf of the international Cardio-Oncology Society. Priorities in CardioOncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review. <em>JACC: Cardiooncology<\/em> doi: 10.1016\/j.jaccao.2023.08.003 in press.<\/li>\n<li>Kodogo V, Viljoen C, Hoevelmann J, Chakafana G, Tromp J, Farhan HA, Goland S, van der Meer P, Karaye K, Kryczka K, <strong>Hilfiker-Kleiner D<\/strong>, Jackson A, Mebazaa A, B\u00f6hm M, Pieske B, <strong>Bauersachs J<\/strong>, Bell L, Sliwa K; EURObservational Research Programme in conjunction with the Heart Failure Association of the European Society of Cardiology on Peripartum Cardiomyopathy. Proteomic Profiling in Patients with Peripartum Cardiomyopathy: A Biomarker Study of the ESC EORP PPCM Registry<em>. JACC Heart Fail.<\/em> 2023 Sep 20:S2213-1779(23)00520-6. doi:10.1016\/j.jchf.2023.07.028. Online ahead of print.<\/li>\n<li>Tromp J, Jackson AM, Abdelhamid M, Fouad D, Youssef G, Petrie MC, <strong>Bauersachs J<\/strong>, Sliwa K, van der Meer P; Investigators of the ESC EORP PPCM Registry. <em>Eur J Heart Fail.<\/em> 2023;25(8):1464-1466. doi: 10.1002\/ejhf.2871.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, Auber B, Pabst B, <strong>Agca KC<\/strong>, <strong>Berliner D<\/strong>, <strong>K\u00f6nig T<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>, <strong>Bauersachs J<\/strong>, <strong>Ricke-Hoch M.<\/strong> Prevalence of HSPB6 gene variants in peripartum cardiomyopathy: Data from the German PPCM registry. <em>Int J Cardiol.<\/em> 2023;379:96-99. doi:10.1016\/j.ijcard.2023.03.028.<\/li>\n<li>Weber AL,<strong> Pfeffer TJ<\/strong>, Leitolf H, Ringe B, Wedemeyer H, <strong>Bauersachs J<\/strong>, Sch\u00e4fer A. Cardiogenic shock due to a spontaneously ruptured pheochromocytoma: a rare but life-threatening event-a case report.<em> Clin Res Cardiol. <\/em>2022;111(12):1401-1403. doi: 10.1007\/s00392-022-02115-x.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, <strong>K\u00f6nig T<\/strong>, <strong>Berliner D<\/strong>, <strong>Bauersachs J<\/strong>. Peripartum Cardiomyopathy. Dtsch Med Wochenschr. 2022;147(23):1537-1544. doi: 10.1055\/a-1810-9318.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, <strong>List M<\/strong>, Schippert C, Auber B, <strong>Ricke-Hoch M<\/strong>, <strong>Abou-Moulig V<\/strong>, <strong>Berliner D<\/strong>, <strong>Bauersachs J<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>. High prevalence of reduced fertility and use of assisted reproductive technologies in a German cohort of patients with peripartum cardiomyopathy.<em> Clin Res Cardiol. <\/em>2023;112(3):343-352. doi: 10.1007\/s00392-022-02034.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, <strong>Mueller JH<\/strong>, <strong>Haebel L<\/strong>, <strong>Erschow S<\/strong>, <strong>Yalman KC<\/strong>, Talbot SR, <strong>Koenig T<\/strong>, <strong>Berliner D<\/strong>, <strong>Zwadlo C<\/strong>, Scherr M, <strong>Hilfiker-Kleiner D<\/strong>, <strong>Bauersachs J<\/strong>, <strong>Ricke-Hoch M<\/strong>. Cabergoline treatment promotes myocardial recovery in peripartum cardiomyopathy.<em> ESC Heart Fail. <\/em>2023;10(1):465-477. doi: 10.1002\/ehf2.14210.<\/li>\n<li><strong>Berliner D. <\/strong>Li T, Mariani S, Hamdan R, Hanke J,<strong> K\u00f6nig T<\/strong>,<strong> Pfeffer TJ, Abou-Moulig V, <\/strong>Dogan G,<strong> Hilfiker-Kleiner D, <\/strong>Haverich A,<strong> Bauersachs J, <\/strong>Schmitto JD<strong>. <\/strong>Clinical characteristics and long-term outcomes in patients with peripartum cardiomyopathy (PPCM) receiving left ventricular assist devices (LVAD). Artif Organs. 2023;47((2):417-424. doi: 10.1111\/aor.14406.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, Neuser J, Mueller-Leisse J, Hohmann S, Duncker D,<strong> Bauersachs J<\/strong>, Veltmann C,<strong> Berliner D<\/strong>. Acute echocardiographic and electrocardiographic effects of triggered left ventricular pacing.<em> PLoS One. <\/em>2022;17(12):e0278531. doi: 10.1371\/journal.pone.0278531.<\/li>\n<li>Weber AL,<strong> Pfeffer TJ<\/strong>, Leitolf H, Ringe B, Wedemeyer H, <strong>Bauersachs J<\/strong>, Sch\u00e4fer A. Cardiogenic shock due to a spontaneously ruptured pheochromocytoma: a rare but life-threatening event-a case report.<em> Clin Res Cardiol. <\/em>2022;111(12):1401-1403. doi: 10.1007\/s00392-022-02115-x.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, <strong>K\u00f6nig T<\/strong>, <strong>Berliner D<\/strong>, <strong>Bauersachs J<\/strong>. Peripartum Cardiomyopathy. Dtsch Med Wochenschr. 2022;147(23):1537-1544. doi: 10.1055\/a-1810-9318.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, <strong>Mueller JH<\/strong>, <strong>Haebel L<\/strong>, <strong>Erschow S<\/strong>, <strong>Yalman KC<\/strong>, Talbot SR, <strong>Koenig T<\/strong>, <strong>Berliner D<\/strong>, <strong>Zwadlo C<\/strong>, Scherr M, <strong>Hilfiker-Kleiner D<\/strong>, <strong>Bauersachs J<\/strong>, <strong>Ricke-Hoch M<\/strong>. Cabergoline treatment promotes myocardial recovery in peripartum cardiomyopathy.<em> ESC Heart Fail. <\/em>2022; doi: 10.1002\/ehf2.14210 online ahead of print.<\/li>\n<li><strong>Berliner D. <\/strong>Li T, Mariani S, Hamdan R, Hanke J,<strong> K\u00f6nig T<\/strong>,<strong> Pfeffer TJ, Abou-Moulig V, <\/strong>Dogan G,<strong> Hilfiker-Kleiner D, <\/strong>Haverich A,<strong> Bauersachs J, <\/strong>Schmitto JD<strong>. <\/strong>Clinical characteristics and long-term outcomes in patients with peripartum cardiomyopathy (PPCM) receiving left ventricular assist devices (LVAD). Artif Organs. 2022 Sep 16. doi: 10.1111\/aor.14406. online ahead of print.<\/li>\n<li>Hoes MF, Arany Z,<strong> Bauersachs J, Hilfiker-Kleiner D<\/strong>, Petrie MC, Sliwa K, van der Meer P. Pathophysiology and risk factors of peripartum cardiomyopathy. Nat Rev Cardiol. 2022;19(8):555-565. doi: 10.1038\/s41569-021-00664-8.<\/li>\n<li><strong>Heimerl M*<\/strong>, <strong>Gausepohl T<\/strong>*, <strong>Mueller JH<\/strong>, <strong>Ricke-Hoch M<\/strong>. Neuraminidases \u2013 Key Players in the Inflammatory Response after Pathophysiological Cardiac Stress and Potential New Therapeutic Targets in Cardiac Disease.<em> Biology <\/em>2022;11, 1229. doi: 10.3390\/biology11081229.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, <strong>List M<\/strong>, Schippert C, Auber B, <strong>Ricke-Hoch M<\/strong>, <strong>Abou-Moulig V<\/strong>, <strong>Berliner D<\/strong>, <strong>Bauersachs J<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>. High prevalence of reduced fertility and use of assisted reproductive technologies in a German cohort of patients with peripartum cardiomyopathy.<em> Clin Res Cardiol. <\/em>2022; doi: 10.1007\/s00392-022-02034 online ahead of print.<\/li>\n<li>Kirchhoff H*, <strong>Ricke-Hoch M*<\/strong>, Wohlan K, <strong>Pietzsch S<\/strong>, Karsli \u00dc, <strong>Erschow S<\/strong>, Zweigerdt R, Ganser A, Eder M, Scherr M<sup>#<\/sup>, <strong>Hilfiker-Kleiner D<\/strong><sup>#<\/sup>. Chemotherapy-free targeted anti-BCR-ABL+ acute lymphoblastic leukemia therapy may benefit the heart.<em> Cancers <\/em>2022;14,983. doi: 10.3390\/cancers14040983.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, <strong>Berliner D<\/strong>, <strong>Bauersachs J<\/strong>. Peripartum Cardiomyopathy is missing. Dtsch Arztebl Int. 2022;119(4):57. doi: 10.3238\/arztebl.m2022.0031.<\/li>\n<li><strong>Pietzsch S<\/strong>, Wohlan K, Thackeray JT, <strong>Heimerl M<\/strong>, Schuchardt S, Scherr M, <strong>Ricke-Hoch M<sup>#<\/sup><\/strong>, <strong>Hilfiker-Kleiner D<\/strong><sup>#<\/sup>. Anthracacline-free tumor elimination in mice leads to functional and molecular cardiac recovery from cancer-induced alterations in contrast to longlasting doxorubicin treatment effects.<em> Basic Res Cardiol.<\/em> 2021;116(1):61. doi: 10.1007\/s00395-021-00902-7.<\/li>\n<li>Jackson AM, Petrie MC, Frogoudaki A, Laroche C, Gustafsson F, Ibrahim B, Mebazaa A, Johnson MR, Seferovic PM, Regitz-Zagrosek V, Mbakwem A, B\u00f6hm M, Prameswari HS, Fouad DA, Goland S, Damasceno A, Karaye K, Farhan HA, Hamdan R, Maggioni AP, Sliwa K, <strong>Bauersachs J, <\/strong>van der Meer P, PPCM Investigators Group. Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry. <em>Eur J Heart Fail. <\/em>2021;23(12):2058-2069. doi: 10.1002\/ejhf.2264.<\/li>\n<li>Sliwa K, <strong>Bauersachs J<\/strong>, Arany Z, Spracklen TF, <strong>Hilfiker-Kleiner D<\/strong>. Peripartum cardiomyopathy: From genetics to management. <em>Eur Heart J.<\/em> 2021;42(32):3094-3102. doi: 10.1093\/eurheartj\/ehab458.<\/li>\n<li><strong>Ricke-Hoch M*<\/strong>, <strong>Stelling E<\/strong>*, Lasswitz L, Gunesch AP, <strong>Kasten M<\/strong>, Zapatero-Belinch\u00f3n FJ, Brogden G, Gerold G, Pietschmann T, Montiel V, Balligand JL, Facciotti F, Hirsch E, Gausepohl T, Elbahesh H, Rimmelzwaan GF, H\u00f6fer A, K\u00fchnel MP, Jonigk D, Eigendorf J, Tegtbur U, Mink L, Scherr M, Illig T, Schambach A, <strong>Pfeffer TJ<\/strong>, Hilfiker A, Haverich A, <strong>Hilfiker-Kleiner D<\/strong>. Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease. <em>PLoS ONE<\/em> 2021;16(8):e0255335. doi:org\/10.1371\/journal.pone.0255335. <strong>Pfeffer TJ<\/strong>, <strong>List M<\/strong>, <strong>M\u00fcller JH<\/strong>, Scherr M, <strong>Bauersachs J<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>* and <strong>Ricke-Hoch M*<\/strong>. Perhexiline treatment improves toxic effects of b-adrenergic receptor stimulation in experimental peripartum cardiomyopathy.<em> ESC Heart Fail.<\/em> 2021;8(4):3375-3381. doi:10.1002\/ehf2.13412.<\/li>\n<li>Feyen E*, <strong>Ricke-Hoch M*<\/strong>, Van Fraeyenhove J, Vermeulen Z, Scherr M, Dugaucquier L, Viereck J, Bruyns T, Thum T, Segers VFM, <strong>Hilfiker-Kleiner D<\/strong>* and De Keulenaer GW*. ERBB4 and multiple microRNAs that target ERBB4 participate in pregnancy-related cardiomyopathy.<em> Circ Heart Fail.<\/em> 2021;14(7):e006898. doi: 10.1161\/CIRCHEARTFAILURE.120.006898.<\/li>\n<li><strong>Stelling E<\/strong>*, <strong>Ricke-Hoch M*<\/strong>, <strong>Erschow S<\/strong>, Hoffann S, Bergmann AK, <strong>Heimerl M<\/strong>, <strong>Pietzsch S<\/strong>, Battmer K, Haase A, <strong>Stapel B<\/strong>, Scherr M, Balligand JL, Binah O, <strong>Hilfiker-Kleiner D<\/strong>. Increased prostaglandin-D2 in male STAT3-deficient hearts shifts cardiac progenitor cells from endothelial to white adipocyte differentiation.<em> PLoS Biol. <\/em>2020;18(12):e3000739. doi: 10.1371\/journal.pbio.3000739. eCollection 2020.<\/li>\n<li>Hoes MF*, Bomer N*, <strong>Ricke-Hoch M*<\/strong>, de Jong TV, Arevalo Gomez KF, <strong>Pietzsch S<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>, van der Meer P#. Human iPSC-derived cardiomyocytes of peripartum patients with cardiomyopathy reveal aberrant regulation of lipid metabolism. Circulation 2020;142(23):2288-2291.<\/li>\n<li>Sliwa K, Petrie MC, van der Meer P, Mebazaa A, <strong>Hilfiker-Kleiner D<\/strong>, Jackson AM, Maggioni AP, Laroche C, Regitz-Zagrosek V, \u2026, Ponikowski P, Van Veldhuisen DJ, McMurray J, <strong>Bauersachs J<\/strong>. Clinical presentation, management and 6-month outcomes in women with peripartum cardiomyopathy, an ESC EORP registry. Eur Heart J. 2020;41(39):3787-3797.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, <strong>Pietzsch S<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>. Common genetic predisposition for heart failure and cancer. Herz. 2020;45(7):632-636.<\/li>\n<li>Sieweke JT, Akin M, Stetskamp S, Riehle C, Jonigk D, Flierl U, <strong>Pfeffer TJ<\/strong>, Hirsch V, Dutzmann J, Hoeper, MM, K\u00fchn C, <strong>Bauersachs J<\/strong>, Sch\u00e4fer A. Mechanical circulatory support in refractory cardiogenic shock due to influenza virus-related myocarditis. Eur Respir J. 2020;56(3):2000925.<\/li>\n<li><strong>Heimerl M<\/strong>, Sieve I, <strong>Ricke-Hoch M,<\/strong> <strong>Erschow S<\/strong>, Battmer K, Scherr M, <strong>Hilfiker-Kleiner D<\/strong>. Neuraminidase-1 promotes heart failure after Ischemia\/reperfusion injury by affecting cardiomyocytes and invading monocytes\/macrophages. Basic Res Cardiol. 2020;115(6):62.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, Herrmann J<strong>, Berliner D<\/strong>, <strong>K\u00f6nig T<\/strong>, Winter L, <strong>Ricke-Hoch M<\/strong>, Ponimaskin E, Schuchardt S, Thum T, <strong>Hilfiker-Kleiner D<\/strong>, <strong>Bauersachs J<\/strong>, Kahl, K. Assessment of major mental disorders in a German peripartum cardiomyopathy cohort. ESC Heart Fail. 2020 Sep 10. Doi:10.1002\/ehf2.12967.<\/li>\n<li><strong>Ricke-Hoch M*<\/strong>, Hoes MF*, <strong>Pfeffer TJ<\/strong>*, <strong>Schlothauer MS<\/strong>, Nonhoff J, Haidari S, Bomer N, Scherr M, Stapel B, Stelling E, Kiyan Y, Falk C, Haghikia A, Binah O, Arany Z, Thum T, <strong>Bauersachs J<\/strong>, van der Meer P, <strong>Hilfiker-Kleiner D<\/strong>. In peripartum cardiomyopathy plasminogen activator inhibitor-1 is a potential new biomarker with controversial roles. Cardiovasc Res. 2020 Sep 1;116(11):1875-1886.<\/li>\n<li>Sliwa K, <strong>Bauersachs J<\/strong>, Coats AJS. The European Society of Cardiology Herat Failure Association Study Group on Peripartum Cardiomyopathy \u2013 what has been achieved in 10 years. Eur J Heart Fail. 2020;22(7):1060-1064.<\/li>\n<li>Sieweke JT* , <strong>Pfeffer TJ<\/strong>*, <strong>Berliner D<\/strong>, <strong>K\u00f6nig T<\/strong>, Hallbaum M, Napp LC, Tongers J, K\u00fchn C, Schmitto JD, <strong>Hilfiker-Kleiner D<\/strong>, Sch\u00e4fer A, <strong>Bauersachs J<\/strong>.\u00a0 Cardiogenic shock complicating peripartum cardiomyopathy: Importance of early left ventricular unloading and bromocriptine therapy, Eur Heart J Acute Cardiovasc Care 2020; 9(2):173-182.<\/li>\n<li>Sieweke JT<strong>*<\/strong>, <strong>Pfeffer TJ*<\/strong>, Biber S, Chatterjee S, Weissenborn K, Grosse GM, Hagemus J, Derda AA, <strong>Berliner D<\/strong>, Lichtinghagen R, <strong>Hilfiker-Kleiner D<\/strong>, <strong>Bauersachs J<\/strong>, B\u00e4r C, Thum T, Bavendiek U. miR-21 and NT-proBNP correlate with echocardiographic parameters of atrial dysfunction and predict atrial fibrillation. J Clin Med. 2020;9(4):1118.<\/li>\n<li><strong>Ricke-Hoch M<\/strong>, <strong>Pfeffer TJ<\/strong> and <strong>Hilfiker-Kleiner D<\/strong>. Peripartum cardiomyopathy: basic mechanisms and hope for new therapies. Cardiovasc Res. 2020;116(3):520-531.<\/li>\n<li>Azibani F*, <strong>Pfeffer TJ<\/strong>*, <strong>Ricke-Hoch M<\/strong>, Dowling W, <strong>Pietzsch S<\/strong>, Briton O, Baard J, <strong>Moulig V<\/strong>, <strong>K\u00f6nig T<\/strong>, <strong>Berliner D<\/strong>, Libhaber E, <strong>Schlothauer S<\/strong>, Anthony J, Lichtinghagen R, <strong>Bauersachs J<\/strong>, Sliwa K#, <strong>Hilfiker-Kleiner D<\/strong>#. Outcome in German and South African Peripartum Cardiomyopathy cohorts associates with medical therapy and fibrosis markers. ESC Heart Fail. 2020;7(2):512-522.<\/li>\n<li><strong>Bauersachs J<\/strong>, <strong>K\u00f6nig T<\/strong>, van der Meer P, Petrie MC, <strong>Hilfiker-Kleiner D<\/strong>, \u2026, Anker SD, Ponikowski P, Seferovic PM, Johnson MR, Mebazaa A, Sliwa K. Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the HFA of the ESC Study Group on peripartum cardiomyopathy. Eur J Heart Fail. 2019;21(7):827-843.<\/li>\n<li><strong>Pfeffer TJ<\/strong>*, <strong>Schlothauer S<\/strong>*, <strong>Pietzsch S<\/strong>, Schaufelberger M, Auber B, <strong>Ricke-Hoch M<\/strong>, List M, <strong>Berliner D<\/strong>, <strong>Abou Moulig V<\/strong>, <strong>K\u00f6nig T<\/strong>, Arany Z, Sliwa K, <strong>Bauersachs J<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>. Increased cancer prevalence in peripartum cardiomyopathy. JACC: CardioOncology Vol 1 No.2, 2019.<\/li>\n<li><strong>Moulig V<\/strong>*, <strong>Pfeffer TJ<\/strong>*, <strong>Ricke-Hoch M<\/strong>, <strong>Schlothauer S<\/strong>, <strong>Koenig T<\/strong>, Schwab J, <strong>Berliner D<\/strong>, Pfister R, Michels G, Haghikia A, Falk CS, Duncker D, Veltmann C, <strong>Hilfiker-Kleiner D<\/strong>#, <strong>Bauersachs J<\/strong>#. Long-term follow-up in peripartum cardiomyopathy patients with contemporary treatment: low mortality, high cardiac recovery, but significant cardiovascular co-morbidities. Eur J Heart Fail. 2019;21(12):1534-1542.<\/li>\n<li>Haghikia A, Schwab J, Vogel-Claussen J, <strong>Berliner D<\/strong>, <strong>Pfeffer T<\/strong>, <strong>K\u00f6nig T<\/strong>, Zwadlo C, <strong>Moulig VA<\/strong>, Franke A, Schwarzkopf M, Ehlermann P, Pfister R, Michels G, Westenfels R, Stangl V, K\u00fchl U, Podewski E, Kindermann I, B\u00f6hm M, Sliwa K, <strong>Hilfiker-Kleiner D<\/strong>. <strong>Bauersachs J<\/strong>. Bromocritine treatment in patients with peripartum cardiomyopathy and right ventricular dysfunction. Clin Res Cardiol. 2019;108(3):290-297.<\/li>\n<li><strong>Pietzsch S<\/strong>, <strong>Ricke-Hoch M<\/strong>, Stapel B, <strong>Hilfiker-Kleiner D<\/strong>. Data on left ventricular expression of STAT3 and AKT in transgenic mouse models with B16F10 melanoma. Data Brief. 2019;26:104508 104508.<\/li>\n<li><strong>Pietzsch S<\/strong>, <strong>Ricke-Hoch M<\/strong>, Stapel B, <strong>Hilfiker-Kleiner D<\/strong>. Modulation of cardiac AKT and STAT3 signalling in preclinical cancer models and their impact. Biochim Biophys Acta Mol Cell Res. 2020;1867(3):118519.<\/li>\n<li>Scherr M, Kirchhoff H, Battmer K, Wohlan K, Lee CW, <strong>Ricke-Hoch M<\/strong>, <strong>Erschow S<\/strong>, Law E, Kloos A, Heuser M, Ganser A, <strong>Hilfiker-Kleiner D<\/strong>, Heidenreich O, Eder M. Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia. Leukemia 2019;33(6):1313-1323.<\/li>\n<li><strong>Pfeffer TJ<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>. Pregnancy and Heart Disease: Pregnancy-Associated Hypertension and Peripartum Cardiomyopathy, Curr Probl Cardiol. 2018 Sep;43(9):364-388.<\/li>\n<li>*Sieve I, <strong>*Ricke-Hoch M<\/strong>, <strong>Kasten M<\/strong>, Battmer K, <strong>Stapel B<\/strong>, Falk CS, Leisegang MS, Haverich A, Scherr M, <strong>Hilfiker-Kleiner D<\/strong>. A positive feedback loop between IL-1b, LPS, and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages. Vascul. Pharmacol. 2018;103-105:16-28.<\/li>\n<li>Bollen IAE, Ehler E, Fleischanderl K, Bouwman F, Kempers L, <strong>Ricke-Hoch M<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>, Dos Remedios CG, Kr\u00fcger M, Vink A, Asselbergs FW, van Spaendonck-Zwarts KY, Pinto YM, Kuster DWD, van der Velden J. Myofilament remodeling and function is more impaired in peripartum cardiomyopathy compared with dilated cardiomyopathy and ischemic heart disease. Am J Pathol. 2017;187(12):2645-2658.<\/li>\n<li><strong>Hilfiker-Kleiner D<\/strong>, Haghikia A, <strong>Berliner D<\/strong>, Vogel-Claussen J, Schwab J, Franke A, Schwarzkopf M, Ehlermann P, Pfister R, Westenfeld r, Stangl V, Kindermann I, K\u00fchl U, Angermann C, Schlitt A, Fischer D, Podewski E, B\u00f6hm M, Sliwa K and <strong>Bauersachs J.<\/strong> Bromocriptine for the Treatment of Peripartum Cardiomyopathy: A Multicenter Randomized Study. <i>European heart journal<\/i>. 2017, 38(35):2671-2679.<\/li>\n<li>Thackeray JT, <strong>Pietzsch S<\/strong>, Stapel B, <strong>Ricke-Hoch M<\/strong>, Lee CW, Bankstahl JP, Scherr M, Heineke J, Scharf G, Haghikia A, Bengel FM and <strong>Hilfiker-Kleiner D<\/strong>. Insulin supplementation attenuates cancer-induced cardiomyopathy and slows tumor disease progression. JCI Insight. 2017;2(10):e93098.<\/li>\n<li>Duncker D, Westenfeld R, Konrad T, <strong>Pfeffer TJ<\/strong>, Correia de Freitas CA, Pfister R, Thomas D, F\u00fcrnkranz A, Andri\u00e9 RP, Napp A, Schmitt J, Karolyi L, Wakili R, <strong>Hilfiker-Kleiner D<\/strong>, <strong>Bauersachs J<\/strong>, Veltmann C. Risk for life-threatening arrhythmia in newly diagnosed peripartum cardiomyopathy with low ejection fraction: a German multi-centre analysis. Clin Res Cardiol. 2017 Aug;106(8):582-589.<\/li>\n<li>*Nonhoff J, *<strong>Ricke-Hoch M,<\/strong> *Mueller M, Stapel B, <strong>Pfeffer TJ<\/strong>, <strong>Kasten M<\/strong>, Scherr M, von Kaisenberg C, Bauersachs J, Haghikia A. and <strong>Hilfiker-Kleiner D<\/strong>. Serelaxin treatment promotes adaptive hypertrophy but does not prevent heart failure in experimental peripartum cardiomyopathy. Cardiovasc Res. 2017 May 1;113(6):598-608.<\/li>\n<li>Stapel B, Kohlhaas M, <strong>Ricke-Hoch M<\/strong>, Haghikia A, <strong>Erschow S<\/strong>, Knuuti J, Silvola JM, Roivainen A, Saraste A, Nickel AG, Saar JA, Sieve I, <strong>Pietzsch S,<\/strong> Muller M, Bogeski I, Kappl R, Jauhiainen M, Thackeray JT, Scherr M, Bengel FM, Hagl C, Tudorache I, <strong>Bauersachs J<\/strong>, Maack C and <strong>Hilfiker-Kleiner D<\/strong>. Low STAT3 expression sensitizes to toxic effects of beta-adrenergic receptor stimulation in peripartum cardiomyopathy. Eur Heart J. 2017;38(5):349-361.<\/li>\n<li><strong>Hilfiker-Kleiner D<\/strong>, <strong>Bauersachs J<\/strong>. Herzerkrankungen in der Schwangerschaft [Cardiovascular disease in pregnancy]. Dtsch Med Wochenschr. 2016 Jan;141(2):110-4.<\/li>\n<li>Duncker D, <strong>Bauersachs J<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>, Veltmann C. Underestimated risk for life-threatening ventricular arrhythmias in newly diagnosed peripartum cardiomyopathy? Eur Heart J. 2015 May 7;36(18):1067-8.<\/li>\n<li>Haghikia A, Podewski E, <strong>Berliner D<\/strong>, Sonnenschein K, Fischer D, Angermann CE, B\u00f6hm M, R\u00f6ntgen P, <strong>Bauersachs J<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>. Rationale and design of a randomized, controlled multicentre clinical trial to evaluate the effect of bromocriptine on left ventricular function in women with peripartum cardiomyopathy. Clin Res Cardiol. 2015 Nov;104(11):911-7.<\/li>\n<li><strong>Hilfiker-Kleiner D<\/strong>, Haghikia A, Nonhoff J, <strong>Bauersachs J<\/strong>. Peripartum cardiomyopathy: current management and future perspectives. Eur Heart J. 2015 May 7;36(18):1090-7.<\/li>\n<li>Duncker D, Haghikia A, K\u00f6nig T, Hohmann S, Gutleben KJ, Westenfeld R, Oswald H, Klein H, <strong>Bauersachs J<\/strong>, <strong>Hilfiker-Kleiner D<\/strong>, Veltmann C. Risk for ventricular fibrillation in peripartum cardiomyopathy with severely reduced left ventricular function-value of the wearable cardioverter\/defibrillator. Eur J Heart Fail. 2014 Dec;16(12):1331-6.<\/li>\n<li><strong>Hilfiker-Kleiner D<\/strong> and Sliwa K. Pathophysiology and epidemiology of peripartum cardiomyopathy. Nature reviews Cardiology. 2014;11:364-70.<\/li>\n<li><strong>Ricke-Hoch M<\/strong>, Bultmann I, Stapel B, Condorelli G, Rinas U, Sliwa K, Scherr M, <strong>Hilfiker-Kleiner D<\/strong>. Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress. Cardiovasc Res. 2014 Mar 15;101(4):587-96.<\/li>\n<li>Haghikia A, Podewski E, Libhaber E, Labidi S, Fischer D, Roentgen P, Tsikas D, Jordan J, Lichtinghagen R, von Kaisenberg CS, Struman I, Bovy N, Sliwa K, <strong>Bauersachs J<\/strong> and <strong>Hilfiker-Kleiner D<\/strong>. Phenotyping and outcome on contemporary management in a German cohort of patients with peripartum cardiomyopathy. Basic Res Cardiol. 2013;108:366.<\/li>\n<li>*Halkein J, *Tabruyn SP, *<strong>Ricke-Hoch M<\/strong>, Haghikia A, Nguyen NQN, Scherr M, Castermans K, Malvaux L, Lambert V, Thiry M, Sliwa K, Noel A, Martial JA, <strong>#Hilfiker-Kleiner D<\/strong>, and #Struman I. MicroRNA-146a, a therapeutic target and biomarker for peripartum cardiomyopathy. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, <strong>Hilfiker-Kleiner D<\/strong>, Karumanchi SA, Arany Z. (2012) Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature. 485(7398):333-8.<\/li>\n<li><strong>Hoch M<\/strong>, Fischer P, Stapel B, Missol-Kolka E, Sekkali B, Scherr M, Favret F, Braun T, Eder M, Schuster-Gossler K, Gossler A, Hilfiker A, Balligand JL, Drexler H, <strong>Hilfiker-Kleiner D<\/strong> (2011) Erythropoietin Preserves the Endothelial Differentiation Capacity of Cardiac Progenitor Cells and Reduces Heart Failure during Anticancer Therapies. Cell Stem Cell 9(2): 131-143<\/li>\n<li><strong>Hilfiker-Kleiner D<\/strong>, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H (2007) A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell 128(3): 589-600<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>    <\/div>\n  <\/div>\n<\/div><\/div>\n\n<div class=\"lazyblock-akkordeon-LeeO1 wp-block-lazyblock-akkordeon\">\n<input id=\"frderungen\" class=\"hide-akkordeon akkordeon-toggle\" type=\"checkbox\" tabindex=\"-1\">\n\n<div class=\"akkordeon-block\">\n  <div class=\"toggler\">\n    <label for=\"frderungen\" tabindex=\"0\">F\u00f6rderungen<\/label>\n    <div class=\"akkordeon-bar\"><\/div>\n  <\/div>\n\n  <div class=\"akkordeon-content\">\n    <div class=\"akkordeon-inner-content\">\n      <p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1152\" role=\"img\" src=\"https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/Deutsche_Forschungsgemeinschaft_DFG_Logo-7b8294fc.svg\" alt=\"\" width=\"300\" height=\"300\" \/><br \/><a href=\"http:\/\/www.dfg.de\/\" target=\"_blank\" rel=\"noopener\">Deutsche Forschungsgemeinschaft<\/a><\/p>\n<p>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1154\" src=\"https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/Fondation_Leducq-1de4bcd5-300x131.jpg\" alt=\"\" width=\"300\" height=\"131\" srcset=\"https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/Fondation_Leducq-1de4bcd5-300x131.jpg 300w, https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/Fondation_Leducq-1de4bcd5-768x336.jpg 768w, https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/Fondation_Leducq-1de4bcd5.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/><a href=\"https:\/\/www.fondationleducq.org\/network\/targeted-approaches-for-prevention-and-treatment-of-anthracycline-induced-cardiotoxicity\/\">Fondation Leducq<\/a><\/p>\n<p>\u00a0<\/p>\n<p>Stiftung Gerdes<\/p>\n<p>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1156\" src=\"https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/Gefoerdert_vom_BMBF_Logo-dcdfaaca-300x213.jpg\" alt=\"\" width=\"300\" height=\"213\" srcset=\"https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/Gefoerdert_vom_BMBF_Logo-dcdfaaca-300x213.jpg 300w, https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/Gefoerdert_vom_BMBF_Logo-dcdfaaca-768x545.jpg 768w, https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/Gefoerdert_vom_BMBF_Logo-dcdfaaca.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><br \/><a href=\"https:\/\/www.bmbf.de\" target=\"_blank\" rel=\"noopener\">Bundesministerium f\u00fcr Bildung und Forschung<\/a><\/p>    <\/div>\n  <\/div>\n<\/div><\/div>\n\n<div class=\"lazyblock-akkordeon-3KT8G wp-block-lazyblock-akkordeon\">\n<input id=\"preise\" class=\"hide-akkordeon akkordeon-toggle\" type=\"checkbox\" tabindex=\"-1\">\n\n<div class=\"akkordeon-block\">\n  <div class=\"toggler\">\n    <label for=\"preise\" tabindex=\"0\">Preise<\/label>\n    <div class=\"akkordeon-bar\"><\/div>\n  <\/div>\n\n  <div class=\"akkordeon-content\">\n    <div class=\"akkordeon-inner-content\">\n      <ul>\n<li>1. Platz Posterpreis, Marcus Schaub Young Investigator Award, Dr.\u00a0Maren Heimerl: &#8220;Ribonucleoprotein\/RNA trafficking via unconventional motor protein myosin-5b is essential to guarantee proper cardiac electrical conductance&#8221;,\u00a050th European Muscle Conference, Florenz 2023<\/li>\n<li>1. Preis Hans-Bl\u00f6mer-Young Investigator Award f\u00fcr klinische Herz- und Kreislaufforschung, Julia H. M\u00fcller: &#8220;Genetics forms of peripartum cardiomyopathy: an IPSC-based approach to identify underlying pathomechanisms associated with cardiac dysfunction&#8221;, DGK Jahrestagung Mannheim 2023\u00a0<\/li>\n<li>Posterpreis der Klinischen Forschergruppe 311, Julia H. M\u00fcller: &#8220;Cabergoline treatment promotes myocardial recovery in peripartum cardiomyopathy&#8221;, Symposium of KFO311, Hannover 2022<\/li>\n<li>Tom Force Poster\u00a0Award, Thomas Gausepohl: &#8220;Ataxia-Telangiectasia-Mutaed deficiency is associated with cardiac function in the peripartum phase&#8221;, Leducq Network Meeting Marburg 2022<\/li>\n<\/ul>    <\/div>\n  <\/div>\n<\/div><\/div>\n\n<div class=\"lazyblock-akkordeon-Z14vld9 wp-block-lazyblock-akkordeon\">\n<input id=\"peripartumkardiomyopathieppcm\" class=\"hide-akkordeon akkordeon-toggle\" type=\"checkbox\" tabindex=\"-1\">\n\n<div class=\"akkordeon-block\">\n  <div class=\"toggler\">\n    <label for=\"peripartumkardiomyopathieppcm\" tabindex=\"0\">Peripartum Kardiomyopathie (PPCM)<\/label>\n    <div class=\"akkordeon-bar\"><\/div>\n  <\/div>\n\n  <div class=\"akkordeon-content\">\n    <div class=\"akkordeon-inner-content\">\n      <div class=\"accordion\">\n<div class=\"inner\">\n<div class=\"ce_text block\">\n<p>Bei der PPCM handelt es sich um eine schwangerschaftsbedingte Herzschw\u00e4che, die bei zuvor herzgesunden Frauen gegen Ende der Schwangerschaft, im Rahmen der Entbindung oder in den ersten Monaten danach auftritt. In Deutschland erkrankt ca. eine von 1000-2000 Frauen an einer PPCM.<\/p>\n<p>\u00a0<\/p>\n<p>Ziel unserer Arbeit ist zum einen ein besseres Verst\u00e4ndnis von Entstehung und Verlauf der PPCM, um potentielle Patientinnen noch fr\u00fcher zu identifizieren und einer effektiven Behandlung zuf\u00fchren zu k\u00f6nnen. Zum anderen arbeiten wir an neuen therapeutischen Ans\u00e4tzen um die Behandlung und damit die Prognose der PPCM-Patientinnen weiter zu verbessern. Mit diesem Ziel f\u00fchren wir derzeit mehrere grundlagenwissenschaftliche Projekte mit einem PPCM-Mausmodell und mehrere klinische Studien zur PPCM durch. Au\u00dferdem betreuen wir das deutschlandweite PPCM-Register. Dabei sind in der Arbeitsgruppe Molekulare Kardiologie klinische und experimentelle Forschung eng miteinander verbunden mit dem Ziel einer klinischen Anwendung der so gewonnenen Forschungsergebnisse.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>\u00a0<\/p>\n<p>Die Arbeitsgruppe Molekulare Kardiologie arbeitet mit den neuesten Techniken der Zell- und Molekularbiologie und verwendet f\u00fcr die Untersuchung ihrer Fragestellungen verschiedene Zellkultur- und Tiermodelle wie auch Blutproben aus Patientenstudien.<\/p>\n<p>\u00a0<\/p>\n<p>Die Arbeitsgruppe setzt sich aus promovierten Wissenschaftlerinnen und Wissenschaftlern, technischen Mitarbeiterinnen und Mitarbeitern und Doktorandinnen und Doktoranden der Medizin und Naturwissenschaften zusammen. Erg\u00e4nzt wird das Team durch hoch-motivierte Studierende der naturwissenschaftlichen Masterstudieng\u00e4nge der MHH.<\/p>\n<p>\u00a0<br \/><a href=\"https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/MHH-Kardiologie_PPCM_Faltblatt_Maerz_2021_Web-1.pdf\">Informationsblatt Peripartale Kardiomyopathie (PPCM)\u00a0f\u00fcr Patientinnen\u00a0<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>    <\/div>\n  <\/div>\n<\/div><\/div>\n\n<div class=\"lazyblock-akkordeon-kfQLw wp-block-lazyblock-akkordeon\">\n<input id=\"profdenisehilfiker-kleinerprsidentindermhh\" class=\"hide-akkordeon akkordeon-toggle\" type=\"checkbox\" tabindex=\"-1\">\n\n<div class=\"akkordeon-block\">\n  <div class=\"toggler\">\n    <label for=\"profdenisehilfiker-kleinerprsidentindermhh\" tabindex=\"0\">Prof. Denise Hilfiker-Kleiner | Pr\u00e4sidentin der MHH<\/label>\n    <div class=\"akkordeon-bar\"><\/div>\n  <\/div>\n\n  <div class=\"akkordeon-content\">\n    <div class=\"akkordeon-inner-content\">\n      <p>Frau Prof. Hilfiker-Kleiner ist eine Expertin auf dem Gebiet der Peripartum Kardiomyopathie, kardiovaskul\u00e4rer Erkrankungen und der Kardio-Onkologie. Sie ist Teilprojektleiterin im Leducq Netzwerk \u201eTargeted Approaches for Prevention and Treatment of Anthracycline-Induced Cardiotoxicity.\u201c<\/p>\n<p>Frau Prof. Hilfiker-Kleiner war \u00fcber zwanzig Jahre als erfolgreiche Forscherin und seit 2012 als W3 Professorin f\u00fcr Molekulare Kardiologie an unserer Klinik t\u00e4tig. 2013 \u00fcbernahm sie zudem das Amt der Forschungsdekanin der MHH, welches sie bis M\u00e4rz 2020 innehatte.<\/p>\n<p>Seit 2018 ist sie Mitglied des Wissenschaftsrats, dem wichtigsten wissenschaftspolitischen Beratungsgremium der Bundesregierung. Im Februar 2020 wurde sie zudem als Mitglied in den Aufsichtsrat der Charit\u00e9 in Berlin gew\u00e4hlt. Im Januar 2021 trat Frau Hilfiker-Kleiner ihre neue Stelle als Dekanin des Fachbereichs Medizin in Marburg an.<\/p>\n<p>Wir verdanken ihr insbesondere ihre wissenschaftlichen Leistungen auf dem Gebiet der \u201ePeripartalen Kardiomyopathie (PPCM)\u201c sowie der Krebs-\/assoziierten Kardiomyopathie. Sie hat in der Klinik f\u00fcr Kardiologie und Angiologie hervorragende translationale Forschung umgesetzt und hochrangig publiziert. Sie war essentiell auch f\u00fcr erfolgreiche Drittmitteleinwerbungen wie das Rebirth-Exzellenzcluster und die KFO311. Die von ihr initiierte Studie mit Bromocriptin bei PPCM war Grundlage einer Leitlinienempfehlung der Europ\u00e4ischen Gesellschaft f\u00fcr Kardiologie (ESC).<\/p>\n<p>Zum <strong>1. Januar 2025 <\/strong>trat Frau Prof. Hilfiker-Kleiner ihre neue Stelle als Pr\u00e4sidentin der <strong>MHH <\/strong>an. Wir w\u00fcnschen ihr alles erdenklich Gute sowie Erfolg bei ihrer neuen Aufgabe.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-437\" role=\"img\" src=\"https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2021\/10\/Leistungen.svg\" alt=\"\" width=\"70\" height=\"70\" \/><\/p>    <\/div>\n  <\/div>\n<\/div><\/div>\n\n<div class=\"lazyblock-hyberlink-block-Z1YvhCC wp-block-lazyblock-hyberlink-block\"><a href=\"https:\/\/www.youtube.com\/live\/ixqdUIQ4Dwg\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"hyperlink_txt\">Vortrag &quot;Saving mother hearts &#8211; Neue Therapien gegen M\u00fcttersterblichkeit&quot; | 16.12.2025<\/a><\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\"><div class=\"personal_container\"><div class=\"personal_portrait\" style=\"background-image: url(https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2022\/01\/MHH-1121-Ricke-Hoch-5277-ret-RGB.jpg);\"><\/div><div class=\"personal_infos\"><p class=\"personal_name\">PD Dr. rer. nat. Melanie Ricke-Hoch<\/p><p class=\"personal_mail\"><a href=\"mailto:hoch.melanie@mh-hannover.de\">hoch.melanie@mh-hannover.de<\/a><\/p><\/div><\/div>\n\n\n<div class=\"personal_container\"><div class=\"personal_portrait\" style=\"background-image: url(https:\/\/mhh-kardiologie.de\/wp-content\/uploads\/2024\/11\/MHH_Kardiologie_OA\u0308_Portraits_pfeffer_2024-10-29_web.jpg);\"><\/div><div class=\"personal_infos\"><p class=\"personal_name\"><a href=\"https:\/\/mhh-kardiologie.de\/en\/klinikteam\/direktor-oberaerzte\/dr-tobias-jonathan-pfeffer\/\">PD Dr. Tobias Jonathan Pfeffer<\/a><\/p><p class=\"personal_mail\"><a href=\"mailto:pfeffer.tobias.j@mh-hannover.de\">pfeffer.tobias.j@mh-hannover.de<\/a><\/p><\/div><\/div>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Anschrift<br><\/strong><span class=\"has-inline-color has-luminous-vivid-orange-color\"><strong>Medizinische Hochschule Hannover<br>Molekulare Kardiologie \u00b7&nbsp;OE 6887<br><\/strong>Klinik f\u00fcr Kardiologie und Angiologie<br>Carl-Neuberg-Stra\u00dfe 1<br>30625 Hannover<\/span><\/p>\n\n\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Kontakt zum PPCM-Expertenteam<br><\/strong><a href=\"mailto:ppcm@mh-hannover.de\"><span class=\"has-inline-color has-luminous-vivid-orange-color\">ppcm@mh-hannover.de<\/span><\/a><\/p>\n\n\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Terminanfragen<br><\/strong><span class=\"has-inline-color has-luminous-vivid-orange-color\"><a href=\"https:\/\/mhh-kardiologie.de\/ambulanzen-sprechstunden\/ambulanz-fuer-peripartale-kardiomyopathie-ppcm\/\" data-type=\"page\" data-id=\"159\">Ambulanz f\u00fcr&nbsp;Peripartale Kardiomyopathie (PPCM)<\/a><\/span><\/p>\n\n\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u00c4rztliche Teammitglieder (PPCM)<\/strong><br><a data-type=\"URL\" href=\"mailto:berliner.dominik@mh-hannover.de\">Dr. Dominik Berliner<\/a><br><a data-type=\"mailto\" data-id=\"mailto:koenig.tobias@mh-hannover.de\" href=\"mailto:koenig.tobias@mh-hannover.de\">Dr. Tobias K\u00f6nig<\/a><a href=\"mailto:Pfeffer.Tobias.J@mh-hannover.de\"><br><\/a><a data-type=\"mailto\" data-id=\"mailto:silber-peest.ann@mh-hannover.de\" href=\"mailto:silber-peest.ann@mh-hannover.de\">Dr. Ann Sophie Silber-Peest<\/a><\/p>\n\n\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Wissenschaftliche Mitarbeitende<\/strong><br>Dr. Thomas Gausepohl<br>Dr. Maren Heimerl<br>Hannah K\u00f6nig-Hollrah<br>Julia H. M\u00fcller<br>K\u00fcbra Ceren Agca<\/p>\n\n\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Medizinsche Doktoranden<\/strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-luminous-vivid-orange-color\"><br><\/mark>Victoria Kl\u00fcsch<br>Dennis Petricele<br>Luca Connor R\u00fcdebusch<br>Manuel List<\/p>\n\n\n\n<div style=\"height:1px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Technische Mitarbeitende<\/strong><br>Birgit Brandt (VMTA)<br>Dipl. biotechn. Sergej Erschow<br>Martina Kasten (BTA<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-luminous-vivid-orange-color\"><\/mark>)<\/p>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Molekulare Kardiologie &#8211; Neue Mechanismen und Therapiekonzepte Kardiomyopathien, wie die peripartale Kardiomyopathie (PPCM), k\u00f6nnen zu einer Herzmuskelschw\u00e4che (Herzinsuffizienz) f\u00fchren. Der Schwerpunkt der Arbeitsgruppe \u201eMolekulare Kardiologie \u2013 Neue Mechanismen und Therapiekonzepte\u201c liegt dabei in der Aufkl\u00e4rung von Pathomechanismen und genetischen Ursachen, die zur Entstehung einer Herzinsuffizienz und speziell der PPCM, f\u00fchren k\u00f6nnen. Mit Hilfe dieser Erkenntnisse [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5484,"parent":107,"menu_order":78,"comment_status":"closed","ping_status":"closed","template":"","meta":{"block":"%5B%5D","footnotes":""},"class_list":["post-173","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/mhh-kardiologie.de\/en\/wp-json\/wp\/v2\/pages\/173","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mhh-kardiologie.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mhh-kardiologie.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mhh-kardiologie.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mhh-kardiologie.de\/en\/wp-json\/wp\/v2\/comments?post=173"}],"version-history":[{"count":60,"href":"https:\/\/mhh-kardiologie.de\/en\/wp-json\/wp\/v2\/pages\/173\/revisions"}],"predecessor-version":[{"id":6660,"href":"https:\/\/mhh-kardiologie.de\/en\/wp-json\/wp\/v2\/pages\/173\/revisions\/6660"}],"up":[{"embeddable":true,"href":"https:\/\/mhh-kardiologie.de\/en\/wp-json\/wp\/v2\/pages\/107"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mhh-kardiologie.de\/en\/wp-json\/wp\/v2\/media\/5484"}],"wp:attachment":[{"href":"https:\/\/mhh-kardiologie.de\/en\/wp-json\/wp\/v2\/media?parent=173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}